Primix
Primix kekik, kara turp, zencefil, çambalı, vitamin C içerir. Alkol, gluten, gdo, renklendirici içermez. İçeriğindeki hammaddelerin hiçbir allerjen madde ile teması yoktur. Birçok hekim ve eczacının çalışmaları sonucu formülüze edilmiş olup, Sakarya Üniversitesi Teknokent işbirliği ile geliştirilmiştir. Çocuklar ve yetişkinler için farklı dozlarda kullanılmak üzere etki gösterir.
KAYNAKLAR
KEKİK
Sharifi-Rad M, Varoni EM, Iriti M, Martorell M, Setzer WN, Del Mar Contreras M, Salehi B, Soltani-Nejad A, Rajabi S, Tajbakhsh M, Sharifi-Rad J. Carvacrol and human health: A comprehensive review, Phytother Res. 2018 Sep;32(9):1675-1687.
Fani M, Kohanteb J.J Evid Based Complementary In Vitro Antimicrobial Activity of Thymus vulgaris Essential Oil Against Major Oral Pathogens, Altern Med. 2017 Oct;22(4):660-666.
Ana Paula Perez , Noelia Perez , Carlos Mauricio Suligoy Lozano , Maria Julia Altube , Marcelo Alexandre de Farias , Rodrigo Villares Portugal , Fernanda Buzzola , María Jose Morilla, Eder Lilia Romero The anti MRSA biofilm activity of Thymus vulgaris essential oil in nanovesicles, Phytomedicine. 2019 Apr;57:339-351.
O Borugă , C Jianu , C Mişcă , I Goleţ , A T Gruia , F G Horhat Thymus vulgaris essential oil: chemical composition and antimicrobial activity, J Med Life. 2014;7 Spec No. 3(Spec Iss 3):56-60.
Mohsen Mohammadi , Sabrieh Assadi Shahisaraee , Atiyeh Tavajjohi , Negin Pournoori 4, Samad Muhammadnejad 5, Shahla Roodbar Mohammadi , Reza Poursalehi , Hamid Delavari H Green synthesis of silver nanoparticles using Zingiber officinale and Thymus vulgaris extracts: characterisation, cell cytotoxicity, and its antifungal activity against Candida albicans in comparison to fluconazole, IET Nanobiotechnol 2019 Apr;13(2):114-119.
Azaz AD, Irtem HA, Küçükoğlu M, Başer KHC. Composition and the in vitro antimicrobial activites of the essential oil of some Thymus species, Z. Naturforsch. C., 59, 75-80 (2004)
Dorman HJD, Deans SG. Antimicrobial agents from plants: antiba cterial activity of plant volatile oils, J. Appl. Microbiol., 88, 308-316 (2000).
Inouye S, Takizawa T, Yamaguchi H. Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact, J. Antimicrob. Chemother., 47, 565-573 (2001)
Rasooli I, Mirmostafa SA. Antibacterial properties of thymus pubescens and Thymus serpyllum essential oils, Fitoterapia, 73, 244-250 (2002)
Rota MC, Herrera A, Martinez RM, Sotomayor JA, Jordan MJ. Antimicrobial activity and chemical composition of Thymus vulgaris, Thymus zygis and Thymus hyemalis essential oils Food Control, 19, 681687 (2008).
Çelikel N., Kavas, G. Antimicrobial properties of some essential oils against some pathogenic microorganisms, Czech J. Food Sci., 26, 174-181 (2008)
Cheurfa, M., Allem, R., Sebaihia, M., Belhireche, S. Effect of essential oil of Thymus vulgaris on bacterial pathogens responsible for gastroenteritis, Phytotherapie, 11, 154-160 (2013)
Dorman, HJD., Deans, SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils, J. Appl. Microbiol., 88, 308-316 (2000)
Engelbertz, J., Lechtenberg, M., Studt, L., Hensel, A., Verspohl, EJ. Bioassay-guided fractination of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect, J. Ethnopharmacol., 141- 848-853 (2012)
Goncalves, GMS., Bottaro, M., Nilson, AC. Effect of the Thymus vulgaris essential oil on the growth of Streptococcus mutans, Rev. Cienc. Farm. Basica Apl., 21, 375-380 (2011)
Rota, MC., Herrera, A., Martinez, RM., Sotomayor, JA., Jordan, MC. Antimicrobial activity and chemical composition of Thymus vulgaris, Thymus zygis and Thymus hyemalis essential oils, Food Control, 19, 681-687 (2008)
Salmalian, H., Saghebi, R., Moghadamnia, AA., Bijani, A., Faramarzi, M., Amiri, FN., Bakouei, F., Behmanesh, F., Bekhradi, RC. Comparative effect of Thymus vulgaris and ibuprofen on primary dysmenorrhea: a triple-blind clinical study, J. Intern. Med., 5, 82-88 (2014)
Sokovic, M., Glamoclija, J., Ciric, A., Kataranovski, D., Marin, PD., Vukojevic, J., Brkic, D. Antifungal activity of the essential oil of Thymus vulgaris L. And thymol on experimentally induced dermatomycoses, Drug Dev. Ind. Pharm., 34, 1388-1393 (2008)
Sokovic, MD., Vukojevic, J., Marin, PD., Brkic, DD., Vajs, V., van Griensven, LJLD. Chemical composition of essential oils of Thymus and Mentha speciess and their antifungal activites, Molecules, 14, 238-249 (2009)
Taherian, AA., Babaei, M., Vafaei, AA., Jarrahi, M., Jadidi, M., Sadeghi, H. Antinociceptive effects of hydroalcholic extract of Thymus vulgaris, Pak. J. Pharm. Sci., 22, 83-89 (2009)
Kızıl, S., Hasimi, N., Tolan, V. Biologicial activites of Origanum, Satureja, Thymbra and Thymus species grown in Turkey, J. Essent. Oil Bear. Pl., 17, 460-468 (2014)
Marzouk, B., Edziri, H., Haloui, I., Issawi, M., Chraief, I., El-Ouni, M., Fnina, N., Marzouk, Z. Chemical composition, antibacterial and antioxidant activities of a new chemotype of Tunisian Thymus vulgaris oils growing in Sayada, J. Food Agric. Environ 7, 263-267 (2009)
Nicolic, M., Glamoclija, J., Ferreira, ICFR., Calhelha, RC., Fernandes, A., Markovic, T., Markovic, D., Giweli, A., Sokovic, M. Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. And Reut and Thymus vulgaris L. Essential oils, Ind. Crops Prod., 52, 183-190 (2014)
PDR for Herbal Medicine, 3rd ed., Thomson Helathcare, Montvale, NJ (2004).
ZENCEFİL
Cao, Z, F., Chen, Z. G., Guo, O., Zhang, S. M., Lian, L. X., Luo, L., Hu, W. M., Scavenging effects of ginger on superoxide anion and hydroxyl radical, Zhongguo Zhong Yao Za Zhi, 18, 750-751, 764 (1993)
Chrubasik, S., Pittler, M. H., Roufogalis, B. D., Zingiberis Rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12, 684-701 (2005)
ESCOP Monographs 2nd ed. Thieme, New York, NY (2003).
Jagetia, G. C., Baliga, M. S., Venkatesh, P., Ulloor, J. N., Influence of ginger rhizome (Zingiber officinale Rose) on survival, gluthathione and lipid peroxidation in mice after whole body exposure to gamma radiation, Radiat. Res., 160, 584-592 (2003).
Mascolo, N., Jain, R., Jain, S.C., Capasso, F., Ethnopharmalogic investigation of ginger (Zingiber officinale), J Ethnopharmacol, 27, 129-140 (1989).
Mukhopadhyay M. J., Mukherjee, A., Clastogenic effect of ginger rhizome in mice, Phytother Res., 14, 555-557 (2000).
Schmid, R., Schick, T., Steffen R.i Tschoop, A., Wilk, T., Comparison of seven commonly used agents for prophylaxis of seasickness. J Travel Med. 1 (4), 203-206 (1994).
Weidner, M.S., Sigwart, K., The safety of a ginger extract in the rat. J. Ethnopharmacol., 73, 513-520 (2000).
WHO Monographs on Selected Medicinal Plants, Vol. 1, Geneva (1999).
Van Toorenenbergen, A.W., Dieges, P.H., Immunoglobulin E antibodies against coriander and other spices, J. Allergy Clin. Immunol., 76, 477-481 (1985).
TURP
Barillari J, Cervelatti R, Costa S, ve ark. Antioxidant and choleretic properties of Raphanus sativus L. Sprout extract. J Agric Food Chem. 2006;54:9773-8
Beevi SS, Mangamoori LN, Gowda BB. Polyphenolics profile and antioxidant properties of Raphanus sativus L. Nat Prod Res. 2012;26:557-63.
Ben Salah-Abbes J, Abbes S, Houas Z, Abdel-Wahhab MA, Oueslati R. Zearaleone induces immunotoxicity in mice: possible protective effects of radish extract (Raphanus sativus). Pharm Pharmacol. 2008;60:761-70.
Lugasi A, Blazovics A, Hagymasi K, Kocsis I, Kery A. Antioxidant effect of squeezed juice from black radish (Raphanus sativus L. Var niger) in alimentary hyperlipidaemia in rats. Pyhtother Res. 2005;19:587-91.
BAL
Ansorge S, Reinhold D, Lendeckel U. Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-beta 1 production of human immune cells. Z Naturforsch C. 2003;58:580-9.
Irish J, Blair S, Carter DA. The antibacterial activity of honey derived from Australian flora. PLoS One. 2011;6:e18229.
Zaghloul AA, el-Shattawy HH, Kassem AA, Ibrahim EA, Reddy IK, Khan MA. Honey, a prospective antibiotic: extraction, formulation and stability.
Mesaik MA, Azim MK, Mohiuddin S. Honey modulates oxidative burst of Professional phagocytes. Phytother Res. 2008;22:1404-8.
C VİTAMİNİ (L-ASKORBİK ASİT)
J G Atherton, C C Kratzing, A Fisher The effect of ascorbic acid on infection chick-embryo ciliated tracheal organ cultures by coronavirus Arch Virol. 1978;56(3):195-9.
Han Wang , Renyang Xu , Yongying Shi , Longlong Si , Pingxuan Jiao , Zibo Fan , Xu Han , Xingyu Wu , Xiaoshu Zhou , Fei Yu , Yongmin Zhang , Liangren Zhang , Lihe Zhang , Demin Zhou , Sulong Xiao Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors Eur J Med Chem. 2016 Mar 3;110:376-88.
Harri Hemilä, Vitamin C and Infections Nutrients. 2017 Mar 29;9(4):339.
Harri Hemilä, Vitamin C and SARS coronavirus. J Antimicrob Chemother. 2003 Dec;52(6):1049-50.
C Bucca, G Rolla, W Arossa, E Caria, C Elia, F Nebiolo, S Baldi. Effect of ascorbic acid on increased bronchial responsiveness during upper airway infection.Respiration. 1989;55(4):214-9.